VDR is a gene which encodes a vitamin D receptor protein. This protein regulates calcium absorption as well as bone growth. A variant of the gene (rs2228570 FokI polymorphism) is associated with lower bone mineral density in prepubescent girls of white background.
The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is controlled by the reciprocal pattern, as well as the time off-and-on occupancy of the VDRE between the two components. It is also influenced by chromosomal location and binding preferences for certain hormones. Microarray studies on human cells have revealed that over 100 genes contain VDRE. The VDRE is occupied by transcription repressors in the absence of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.
A virtual data room (VDR) is an online repository for data and documents related to legal, business, or other activities that have limitations on viewing, downloading or printing. It makes use of a central server and an extranet connection that is an Internet connection with restricted access to allow controlled log-on for set time periods during which you can look here users are able to access the data and documents.
Companies that deal with investment bankers and in mergers and acquisitions are among the most common users of VDRs. VDR. They need a secure platform for sharing information with investors or potential buyers in a manner that is transparent, and due diligence may require large amounts of information. Life science companies also use VDRs to store everything from clinical trials results to HIPAA documentation.